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This study examines the effects of text and background color combination and typography of characters on visual performance and visual fatigue of individuals working on a visual display termina] (VDT). Correct percentage of performance, critical fusion frequency, near point of convergence, subjective visual fatigue, and preference ranking of color combinations of 40 participants were collected and analyzed. Color combination had no significant effects on visual performance. Typography significantly affected performance. Aesthetically pleasing but more cluttered characters were detrimental to visual performance. Characters of higher frequency and fewer strokes were identified more accurately. Participants also showed differential preference for color combinations. Red-on-green was ranked inferior to color combinations generally used in computer software. Participants showed no visual fatigue during the VDT work.