Gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols from Piper gibbilimbum |
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Authors: | J Orjala P Mian T Rali O Sticher |
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Affiliation: | Department of Pharmacy, Swiss Federal Institute of Technology (ETH) Zurich, 8057 Zürich, Switzerland. |
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Abstract: | Fractionation of the petroleum ether extract from the leaves of Piper gibbilimbum collected in Papua New Guinea afforded four new alkenylphenols, gibbilimbols A-D (1-4). The structures of the isolates were elucidated by spectroscopic methods, mainly 1D- and 2D-NMR spectroscopy. Gibbilimbols A-D were found to be toxic to brine shrimp with an LC50 of approximately 5 microg/mL. Gibbilimbols A-D were further found to be cytotoxic toward KB nasopharyngal carcinoma cells (ED50 7.8-2.1 microg/mL). All isolates also showed antibacterial activity toward Staphylococcus epidermidis and Bacillus cereus. |
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