| 面包酵母不对称还原制备(S)-1-苯砜基-2-丙醇 |
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| 引用本文： | 石月丹,周子彦,谢玉忠.面包酵母不对称还原制备(S)-1-苯砜基-2-丙醇[J].东北电力学院学报,2006,26(6):59-61. |
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| 作者姓名： | 石月丹 周子彦 谢玉忠 |
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| 作者单位： | 东北电力大学应用化学与生物系 吉林吉林132012(石月丹)，延边大学理学院化学系 吉林延边133000(周子彦，谢玉忠) |
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| 摘 要： | 用自制的溴代丙酮与苯亚磺酸钠反应合成1-苯砜基-2-丙酮,然后利用面包酵母在有机溶剂中不对称催化还原1-苯砜基-2-丙酮,制备了光学活性的手性化合物(S)-1-苯砜基-2-丙醇,此反应具有操作简便、光学产率高等优点,其化学产率可达94%以上,对映体过量值为100%。
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| 关 键 词： | 1-苯砜基-2-丙酮 (S)-1-苯砜基-2-丙醇 面包酵母 不对称还原 |
| 文章编号： | 1005-2992（2006）06-0059-03 |
| 收稿时间： | 2006-05-26 |
| 修稿时间： | 2006年5月26日 |
Preparation of(S)-1-Phenylsulfonyl-2-Propanol through Asymmetric Reduction by Baker's Yeast |
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| SHI Yue-dan,ZHOU Zi-yan,XIE Yu-zhong.Preparation of(S)-1-Phenylsulfonyl-2-Propanol through Asymmetric Reduction by Baker''''s Yeast[J].Journal of Northeast China Institute of Electric Power Engineering,2006,26(6):59-61. |
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| Authors: | SHI Yue-dan ZHOU Zi-yan XIE Yu-zhong |
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| Affiliation: | 1. Applied Chemistry and Biological Engineering College, Northeast Dianli University; 2. Chemistry Department of Science College, Yanbian University |
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| Abstract: | In this paper reaction of asymmetric reduction of 1-Phenylsulfonyl-2-Propanone by baker's yeast in organic solvents has been studied.First,three levels and four factors orthogonal experimental were applied to probe into the condition of this reaction.And then,effects of water quantity,substrate concentration,pH value and reaction time on the reaction yield were systemically studied ulteriorly.At the same time,the kinetics of the reaction was also explored.The results showed that the yield was up to as high as 94% under the optimum conditions,and the enantiomeric excess approached 100%.Data of kinetics were accorded with Michaelis-Menton enzyme catalyze mechanism.The maximum reaction ate and constant of Michaelis-Menton were obtained. |
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| Keywords: | 1-Phenylsulfonyl-2-Propanone (S)-1-Phenylsulfonyl-2Propanol baker's yeast asymmetric reduction |
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