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Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats |
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| Authors: | Seong Shoon Yoon Jaesuk Yun Bong Hyo Lee Hee Young Kim Chae Ha Yang |
| Affiliation: | 1.Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea;2.College of Pharmacy and Medical Research Center, Chungbuk National University, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk 28160, Korea;3.Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea; |
| Abstract: | Acupuncture affects the central nervous system via the regulation of neurotransmitter transmission. We previously showed that Shemen (HT7) acupoint stimulation decreased cocaine-induced dopamine release in the nucleus accumbens. Here, we used the intracranial self-stimulation (ICSS) paradigm to evaluate whether HT stimulation regulates the brain reward function of rats. We found that HT stimulation triggered a rightward shift of the frequency–rate curve and elevated the ICSS thresholds. However, HT7 stimulation did not affect the threshold-lowering effects produced by cocaine. These results indicate that HT7 points only effectively regulates the ICSS thresholds of the medial forebrain bundle in drug-naïve rats. |
| Keywords: | acupuncture intracranial self-stimulation rats medial forebrain bundle cocaine brain reward function |