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Cross‐Coupling in Flow using Supported Catalysts: Mild,Clean, Efficient and Sustainable Suzuki–Miyaura Coupling in a Single Pass |
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| Authors: | Juan de M. Muñ oz,Jesú s Alcá zar,Antonio de la Hoz,Angel Dí az‐Ortiz |
| Abstract: | A mild, clean, practical, sustainable and high yielding procedure for Suzuki–Miyaura cross‐coupling in a single pass using a silica‐supported palladium catalyst is described. The catalyst can be used in more than 30 reactions and for more than 8 h of continuous processing without a decrease in reactivity due to the low leaching observed. Different halides/pseudo‐halides and organoboron compounds can be used without modifying the standard procedure. |
| Keywords: | C?C bond formation cross‐coupling flow chemistry solid‐supported catalyst Suzuki– Miyaura reaction |