| PAAm／PEG／PVP半互穿网络水凝胶的制备、表征及茶碱释放研究． |
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| 引用本文： | 魏清渤,白志洋,王俏,高瑞.PAAm／PEG／PVP半互穿网络水凝胶的制备、表征及茶碱释放研究．[J].化学与生物工程,2013,30(2):47-49,60. |
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| 作者姓名： | 魏清渤 白志洋 王俏 高瑞 |
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| 作者单位： | 延安大学化学与化工学院陕西省化学反应工程重点实验室,陕西延安,716000 |
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| 基金项目： | 陕西省教育厅专项研究计划资助项目，延安大学科研启动基金资助项目 |
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| 摘 要： | 以N，N-亚甲基双丙烯酰胺（N，N-MBA）为交联剂、过硫酸钾（KPS）为引发剂·通过丙烯酰胺（AAm）、聚乙二醇（PEG）和聚乙烯吡咯烷酮（PVP）发生共聚反应制备具有半互穿网络结构的水凝胶PAAm／PEG／PVP。采用红外光谱（FTIR）、热重分析（TG）对水凝胶的结构和热学性质进行了分析，研究了中性条件下水凝胶的溶胀性能，并进一步研究了其负栽茶碱在不同缓冲溶液中的释放行为。
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| 关 键 词： | 半互穿网络水凝胶 溶胀率 药物释放 |
Synthesis,Characterization and Theophylline Release Profiles of PAAm/PEG/PVP Hydrogels with Semi-Interpenetrating Networks |
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| WEI Qing-bo
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BAI Zhi-yang
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WANG Qiao
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GAO Rui.Synthesis,Characterization and Theophylline Release Profiles of PAAm/PEG/PVP Hydrogels with Semi-Interpenetrating Networks[J].Chemistry & Bioengineering,2013,30(2):47-49,60. |
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| Authors: | WEI Qing-bo BAI Zhi-yang WANG Qiao GAO Rui |
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| Affiliation: | (Shanxi Key Laboratory of Chemical Reaction Engineering,College of Chemistry & Chemical Engineering,Yan′an University,Yan′an 716000,China) |
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| Abstract: | The PAAm/PEG/PVP hydrogels with semi-interpenetrating networks（semi-IPN） composed of co-polymer networks of aerylamide （AAm）, polyethylene glycol （PEG） and polyvinylpyrrolidone （PVP） was synthesized by a co-polymerization reaetion in the presence of N, N-methylene bisaerylamide（N, N-MBA） as crosslinker and potassium persulfate （KPS） as initiator. The PAAm/PEG/PVP hydrogels was characterized by using Fourier transform infrared spectroscope （FTIR）,thermogravimetric analysis （TG）. The swelling behav- ior of hydrogels under the neutral conditions was investigated. The in vitro release profiles of the model drug theophylline from the hydrogels was also examined. |
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| Keywords: | hydrogel with semi-interpenetrating networks swelling rate drug release |
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