| 深海枝芽胞杆菌A493产生的新活性物质Z11的抗菌机理 |
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| 引用本文： | 黄典,陈莉,邵宗泽,孙风琴,张少博,林达,张鼎楠,喻子牛,张吉斌. 深海枝芽胞杆菌A493产生的新活性物质Z11的抗菌机理[J]. 化学与生物工程, 2013, 30(2): 20-23 |
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| 作者姓名： | 黄典 陈莉 邵宗泽 孙风琴 张少博 林达 张鼎楠 喻子牛 张吉斌 |
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| 作者单位： | 1. 华中农业大学农业微生物学国家重点实验室生命科学技术学院微生物农药国家工程研究中心,湖北武汉,430070
2. 国家海洋局第三海洋研究所 海洋生物遗传资源重点实验室,福建厦门,361005 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 以一株抗菌谱窄的深海枝芽胞杆菌（Virgibacillus dokdonensis）A493为研究对象，对其产生的新的氨基糖苷类抗菌活性物质Z11抑制水稻黄单胞菌的浓度范围和抗菌作用机理进行了研究。结果表明Z11抑制水稻黄单胞菌的浓度范围为14-56μg·mL^-1；机理研究显示Z11不改变水稻黄单胞菌细胞膜的通透性，但能影响其蛋白质的合成及细胞壁合成关键酶N-乙酰葡糖胺-1-磷酸尿苷酰转移酶（GlmU）的活性。
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| 关 键 词： | 深海枝芽胞杆菌A493 水稻黄单胞菌 活性物质 抗菌机制 |
Antibacterial Mechanism of A Novel Active Substance Z11 from Deep-Sea Virgibacillus Dokdonensis A493 |
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| HUANG Dian , CHEN Li , SHAO Zong-ze , SUN Feng-qin , ZHANG Shao-bo , LIN Da , ZHANG Ding-nan , YU Zi-niu , ZHANG Ji-bin. Antibacterial Mechanism of A Novel Active Substance Z11 from Deep-Sea Virgibacillus Dokdonensis A493[J]. Chemistry & Bioengineering, 2013, 30(2): 20-23 |
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| Authors: | HUANG Dian CHEN Li SHAO Zong-ze SUN Feng-qin ZHANG Shao-bo LIN Da ZHANG Ding-nan YU Zi-niu ZHANG Ji-bin |
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| Affiliation: | 1(1.State Key Laboratory of Agricultural Microbiology,College of Life Science and Technology, National Engineering Research Center for Microbial Pesticides,Huazhong Agricultural University,Wuhan 430070,China;2.Key Laboratory of Marine Biogenetic Resources,Third Institute of Oceanography State Oceanic Administration,Xiamen 361005,China) |
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| Abstract: | A deep-sea Virgibacillus dokdonensis A493, which had a narrow antibacterial spectrum, could produce a new aminoglyeoside antibacterial substance Z11. The inhibition concentration and antibacterial mech- anism of Zll against Xanthomonas oryzae pv. oryzae were investigated. The results showed that the inhibition concentration of Zll was 14-56μg·mL^-1 ,Zll didn＇t change the cell membrane permeability,but affected on protein synthesis and activity of the key enzyme N-acetylglucosamine-l-phosphate uridyltransferase （GlmU）for the synthesis of cell wall. |
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| Keywords: | deep-sea Virgibacillus dokdonensis A493 Xanthomonas oryzae pv. oryzae active substance an-tibacterial mechanism |
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