Release Kinetics of Indomethacin from Polymeric Matrices |
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| Authors: | Jin-Shing Lai Chiao-Hsi Chiang Tsui-Hung Wu |
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| Affiliation: |
a Veterans Pharmaceutical Plant, Chung-Li, Taiwan, ROC
b School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, ROC |
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| Abstract: | Polymeric matrices containing three different concentrations of indomethacin 1, 2 and 4% preparations were prepared. The release kinetics of indomethacin from matrices followed Higuchi equation. The effective diffusivity of indomethacin (Dm) was 1.32 × 10-7 +7.4% cm2/sec. The amount released in 24 hours 2 from 10 cm2 matrices with three different concentrations of indomethacin, were 12.0, 18.6 and 25.0 mg respectively. These matrices may potentially be developed as a transdermal therapeutic system. |
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