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| 锌减轻顺铂诱发肝损伤的超微结构研究 | |
| 引用本文： | 郭延奎,王洪海,戴兴岐,王军,高慧英. 锌减轻顺铂诱发肝损伤的超微结构研究[J]. 电子显微学报, 2002, 21(2): 169-171 |
| 作者姓名： | 郭延奎 王洪海 戴兴岐 王军 高慧英 |
| 作者单位： | 1. 山东农业大学电镜室 2. 泰山医学院 3. 泰安铁路医院,山东,泰安271018 |
| 摘 要： | 本实验用大鼠对顺铂诱发的肝素性作用及锌对肝细胞是否有保护舴作用进行了实验超微病理学研究。结果显示单纯给大鼠腹腔内注射顺铂7mg/kg，可致肝细胞的严重损伤，但加用醋酸锌后，可明显减轻由顺铂诱发的损伤作用。表明锌能有效地保护肝细胞，是肝细胞很好的保护剂。 |
| 关 键 词： | 顺铂 肝细胞 细胞保护 CP 肿瘤 化疗 锌 肝损伤 超微结构 |
| 文章编号： | 1000-6281(2002)02-0169-03 |
Ultrastructural study on administration of zinc to alleviate liver damage caused by cisplatin |
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| GUO Yan kui ,WANG Hong hai ,DAI Xing qi ,WANG Jun ,GAO Hui ying. Ultrastructural study on administration of zinc to alleviate liver damage caused by cisplatin[J]. Journal of Chinese Electron Microscopy Society, 2002, 21(2): 169-171 | |
| Authors: | GUO Yan kui WANG Hong hai DAI Xing qi WANG Jun GAO Hui ying |
| Affiliation: | GUO Yan kui 1,WANG Hong hai 2,DAI Xing qi 3,WANG Jun 3,GAO Hui ying 2 |
| Abstract: | An ultrastructure pathological experiment was conducted to study the liver toxin caused by cisplatin and the protection of zinc to hepatic cells on rat. The result showed that the hepatic cells of the rat were seriously damaged by injecting cisplatin 7mg/kg into intraperitoneal and could be alleviated obviously by administering acetic zinc. It indicates that zinc can be a good protector to hepatic cells to alleviate the damages of cisplatin. |
| Keywords: | cisplatin rat hepatic cell cell protection |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |