Tug of War between Survival and Death: Exploring ATM Function in Cancer |
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| Authors: | Venturina Stagni Veronica Oropallo Giulia Fianco Martina Antonelli Irene Cinà Daniela Barilà |
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| Affiliation: | 1.Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, 00179 Rome, Italy; E-Mails: (V.S.); (V.O.); (G.F.); (M.A.); (I.C.);2.Department of Biology, University of Rome “Tor Vergata”, 00133 Rome, Italy |
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| Abstract: | Ataxia-telangiectasia mutated (ATM) kinase is a one of the main guardian of genome stability and plays a central role in the DNA damage response (DDR). The deregulation of these pathways is strongly linked to cancer initiation and progression as well as to the development of therapeutic approaches. These observations, along with reports that identify ATM loss of function as an event that may promote tumor initiation and progression, point to ATM as a bona fide tumor suppressor. The identification of ATM as a positive modulator of several signalling networks that sustain tumorigenesis, including oxidative stress, hypoxia, receptor tyrosine kinase and AKT serine-threonine kinase activation, raise the question of whether ATM function in cancer may be more complex. This review aims to give a complete overview on the work of several labs that links ATM to the control of the balance between cell survival, proliferation and death in cancer. |
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| Keywords: | ATM kinase cancer development and therapy DNA damage response (DDR) apoptosis receptor tyrosine kinase oxidative stress hypoxia and angiogenesis death receptors stem cells |
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