诊疗用聚氨酯导管的抗凝血研究进展

本文简要介绍了诊疗用聚氨酯 (PU)导管进入体内后的凝血过程 ,分析了影响凝血的部分因素 ,包括材料的硬度、表面电荷、光滑程度、亲疏水性和PU的微相分离结构等 ,本文还重点探讨了改善PU导管材料抗凝血性的途径和方法 ,涉及肝素化、亲水性修饰、白蛋白修饰、类肝素化以及日前逐渐兴起的磷酸盐修饰等

Advances in the Antithrombogenicity of Intravascular Polyurethane Catheters

This article briefly reviewed the blood coagulation procedure of intravascular polyurethane catheters,factors influencing it including stiffness,surface charge,lubricity,hydrophilic hydrophobic balance,and micro separated phase structure of PU.Otherwise this paper discussed emphatically some traditional and recent attempts to improve the antithrombogenicity of polyurethane,such as heparin immobilization,increasing the surface hydrophilicity,protein conditioning,heparinoid modification, and attachment of other biological actives.