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| NK/T细胞淋巴瘤细胞凋亡和细胞增殖特征及意义 | |
| 摘 要： | |
The significance and features of apoptosis and proliferation of NK/T cell lymphoma |
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| Authors: | Dabin Wang Meng Ming Junhua Liu Jianhua Yi Dianding Zou |
| Affiliation: | 1. Department of Pediatrics, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China 2. Department of Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China 3. Department of Pediatrics, Zhongnan Hospital, Wuhan University, Wuhan 430071, China |
| Abstract: | Objective:The aim was to study the features and clinical significance of cell apoptosis and proliferation of NK/T cell lymphoma. Methods:TdT-mediated dUTP nick end labeling and immunohistochemical Streptavidin-peroxidase method were used to study cell apoptosis and the expression of proliferation cell nuclear antigen in 25 NK/T cell lymphoma and 10reactive lymphoid tissues. Results:Apoptotic index (AI) and proliferative index (PI) averaged (1.92% ± 0.86%) and (41.48%± 5.10%) respectively in the 25 NK/T cell lymphomas and (6.70% ± 1.89%) and (20.10% ± 2.77%) in the 10 reactive lymphoid tissues. Compared with reactive lymphoid tissues, AI was significantly reduced in NK/T cell lymphoma (t = 10.80, P < 0.01)while PI significantly increased (t = 12.39, P < 0.01). In addition, in NK/T cell lymphoma, AI and PI were positively related (r = 0.69, P < 0.01). Conclusion:In NK/T cell lymphoma, cell apoptosis is reduced while cell proliferation increased. The imbalance between cell apoptosis and cell proliferation is closely related to the development and progression of NK/T cell lymphoma. |
| Keywords: | NK/T cell lymphoma apoptosis proliferation cell nuclear antigen |
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