| 何首乌对记忆和抗疲劳作用的实验研究 |
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| 引用本文： | 杨萍,王璐.何首乌对记忆和抗疲劳作用的实验研究[J].食品与药品,2010,12(9):318-321. |
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| 作者姓名： | 杨萍 王璐 |
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| 作者单位： | [1]广州市民政局精神病院门诊部,广东广州510430 [2]广东药学院生命科学与生物制药学院,广东广州510006 |
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| 基金项目： | 山东省自然科学基金项目(Y2007C157) |
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| 摘 要： | 目的研究何首乌对小鼠学习记忆的影响及其抗疲劳作用。方法采用跳台、水迷宫试验,爬杆、负重游泳试验以及测定肝糖原,观察低、中、高剂量（2.6,7.8,23.4 g/kg）何首乌提取物改善小鼠记忆和抗疲劳作用的效果。结果 （1）跳台试验高剂量组在第1天测试和24 h后重测试时,小鼠平均错误次数显著减少;水迷宫试验高剂量组小鼠平均错误次数减少;（2）爬杆试验中、高剂量的何首乌提取物能显著延长小鼠杆上坚持的时间。负重试验高剂量组小鼠负重游泳的生存时间明显长于正常组。解剖后的肝糖原测定表明低剂量组肝糖原量明显降低。结论何首乌有改善小鼠记忆获得和明显的抗疲劳作用。
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| 关 键 词： | 何首乌 记忆获得 记忆再现 抗疲劳 |
Experimental Study on Memory Improvement and Anti-fatigue Effects of Polygoni multiflori Radix |
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| YANG Ping,WANG Lu.Experimental Study on Memory Improvement and Anti-fatigue Effects of Polygoni multiflori Radix[J].Food and Drug,2010,12(9):318-321. |
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| Authors: | YANG Ping WANG Lu |
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| Affiliation: | YANG Ping1,WANG Lu2(1.Outpatient Clinic,Affiliated Psychiatric Hospital,Bureau of Civil Affairs of Guangzhou Municipality,Guangzhou 510430,China,2.School of Life Science and Biopharmacology,Guangdong Pharmaceutical University,Guangzhou 510006,China) |
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| Abstract: | Objective To explore the memory improvement and anti-fatigue effects of Polygoni multiflori radix in mice.Methods The memory improvement and anti-fatigue effects of Polygoni multiflori radix extract in mice were observed by the step-down test,water maze test,pole-climbing test,weight-loaded swimming test and hepatic glycogen test(anti-fatigue experiment) with low,middle and high dose(2.6,7.8 and 23.4 g/kg),respectively.Results The step-down test showed that the average number of mistakes was reduced signifi... |
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| Keywords: | Polygoni multiflori radix memory acquisition memory representation anti-fatigue |
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