Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats |
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Authors: | Laura M Braden Kenneth K Carroll |
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Affiliation: | (1) Department of Biochemistry, University of Western Ontario, N6A 5C1 London, Ontario, Canada;(2) Present address: Medical Research Council of Canada, Canada |
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Abstract: | High fat diets promote the development of mammary tumors induced in rats by 7,12-dimethylbenz(a)anthracene (DMBA), and polyunsaturated
fats are more effective than saturated fats. This difference is related to the linoleic acid content of polyunsaturated vegetable
oils, but the amount of linolealte required for maximum tumor promotion appears to be higher than indicated by earlier experiments.
Comparison of the effects of a polyunsaturated vegetable oil (corn oil) containing linoleate with a fish oilo (menhaden oil)
containing polyunsaturated fatty acids derived from linolenic acid showed that higher dietary mammary tumors, while corresponding
levels of menhaden oil had an inhibitory effect. This is further evidence that promotion of mammary tumorigenesis by polyunsaturated
vegetable oils may be mediated by prostaglandins or other biologically active eicosanoids derived from n−6 fatty acids. |
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