| 松树叶蜂性信息素中间体的合成研究 |
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| 引用本文： | 孟?,陈立功,古险峰,宋芸,张素峰,唐四华. 松树叶蜂性信息素中间体的合成研究[J]. 精细化工, 2001, 18(6): 358-359 |
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| 作者姓名： | 孟? 陈立功 古险峰 宋芸 张素峰 唐四华 |
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| 作者单位： | 天津大学药物科学与技术学院, |
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| 基金项目： | 国家教育部高等学校骨干教师基金资助项目&& |
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| 摘 要： | :3,7 二甲基 2 十三醇是松树叶蜂Diprionpini性信息素的前体化合物。设计并研究了一条新的 3,7 二甲基 2 十三醇的合成路线 ,并对该路线中两个重要的中间体 2 甲基 1 溴辛烷和 3 甲基 4,4 [1′,2′ 丙二氧基 2 戊酮进行了合成研究。丙二酸二乙酯经己基化、甲基化、水解、脱羧、还原、溴化得到 2 甲基 1 溴辛烷 ,单程总收率为 2 8 4%。 2 ,4 戊二酮经甲基化、单羰基保护得到3 甲基 4,4 (1′ ,2′ 丙二氧基 ) 2 戊酮 ,单程总收率为 15 0 %
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| 关 键 词： | 松树叶蜂 性信息素 3,7二甲基2十三醇 2甲基1溴辛烷 3甲基4,4(1′,2′丙二氧基)2戊酮 |
| 文章编号： | 1003-5214(2001)06-0356-04 |
Synthesis of the Intermediates of Sex Pheromone of Pine Sawfly |
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| Meng Yi,CHEN Li-gong,GU Xian-feng,SONG Yun,ZHANG Su-feng,TANG Si-hua. Synthesis of the Intermediates of Sex Pheromone of Pine Sawfly[J]. Fine Chemicals, 2001, 18(6): 358-359 |
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| Authors: | Meng Yi CHEN Li-gong GU Xian-feng SONG Yun ZHANG Su-feng TANG Si-hua |
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| Abstract: | 3,7-Dimethyl-2-tridecanol is the precursor compound of the sex pheromone of pine sawtly (Diprion pini).A new route of synthesis for 3,7-dimethyl-2-tridecanol was studied in this paper,and the two important intermediates were synthesized.1-Bromo-2-methyloctane was obtained from diethyl malonate through hexylation,methylation,hydrolysis,decarboxylation,reduction and bromination,the overall yield being about 28.4%.3-Methyl-4,4-(1′2′-propylenedioxy)-2-pentanone was prepared from 2,4-pentanedione through methylation and carbonyl-protection,the overall yield being about 15.0%. |
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| Keywords: | pine sawfly sex pheromone 3,7 dimethyl 2 tridecanol 1 bromo 2 methyloctane 3 Methyl 4,4 (1′2′ propylenedioxy) 2 pentanone |
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