高效氟吡甲禾灵的合成

研究了以对苯二酚及2,3-二氯-5-三氟甲基吡啶为原料,碳酸钾为缚酸剂,合成得到2-(4-羟基苯氧基)-3-氯-5-三氟甲基吡啶,再与S-2-氯丙酸甲酯合成得到高效氟吡甲禾灵。讨论了溶剂、反应时间、反应温度对合成高效氟吡甲禾灵的影响。结果表明,以N,N-二甲基乙酰胺为溶剂,碳酸钾为缚酸剂,在65℃下反应12h,高效氟吡甲禾灵的收率可以达到95.6%,光学纯度可以达到97.5%。此方法收率高,光学纯度好,具有工业化意义。

Synthesis of R-(+)-Haloxyfop-methyl

2-（4-Hydroxyphenoxy）-3-chloro-5-trifluoromethylpyridine was synthesized by monoetherification of hydroquinone with 2,3-dichlor-5-trifluoromethylpyridine. R-（＋）-haloxyfop-methyl was prepared through the etherifying between 2-（4-hydroxyphenoxy）-3-chloro-5-trifluoromethylpyridine and S-（-）-methyl 2-chloropropionate. The influences of solvent, reaction time and reaction temperature on the production yield were investigated. Suitable reaction parameters for the synthesis were obtained as follows： solvent was DMAC; potassium carbonate was acid-binding agent; the mixture was reacted for 12 h at 65℃. The yield was 95.6%, and the optical purity was 97.5%.