高温液态水中烟腈水解反应动力学

为了开发烟酸和烟酰胺的绿色制备方法以及探讨高温液态水中腈类物质的水解规律,研究了高温液态水中烟腈的无催化水解反应动力学.考察了实验数据的重现性以及烟腈初始质量浓度对反应动力学的影响,测定了48315～52315 K下烟腈及其水解的中间产物烟酰胺的水解反应动力学数据.结果表明,在不同的实验条件下,烟腈水解可以高选择性地得到烟酰胺或烟酸；烟腈水解为一级连串反应；烟腈和烟酰胺水解反应活化能分别为652和858 kJ/mol；本研究为烟酸和烟酰胺的绿色制备以及高温液态水中腈类化合物水解规律的探讨提供了重要的基础数据.

Kinetics of 3-cyanopyridine hydrolysis in high temperature liquid water

Hydrolysis of 3-cyanopyridine in high temperature liquid water was determined without added catalysts in order to exploit green preparation technology of nicotinic acid and nicotinamide. The hydrolysis reaction kinetics of 3-cyanopyridine and its intermediate nicotinamide was studied from 48315 to 52315 K after investigating the repeatability of experiment data and the influence of initial concentration of 3-cyanopyridine on reaction. Results showed that selective production of nicotinamide or nicotinic acid was possible at different reaction conditions; the hydrolysis of 3-cyanopyridine was consecutive first-order reaction; the activation energies evaluated were 652 kJ/mol for 3-cyanopyridine hydrolysis and 858 kJ/mol for nicotinamide hydrolysis. The results provide an important basic data for the green preparation of nicotinic acid and nicotinamide and exploring the rule of nitriles hydrolysis in high temperature liquid water.