Anti-hypertensive effects of rosiglitazone on renovascular hypertensive rats: role of oxidative stress and lipid metabolism |
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Authors: | LI Yan GUO Nan FU Zhen-ping DONG Ji-rui ZHAO Jian-pu FENG Hui-hong LIU Pin-duo and XIA Yu |
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Affiliation: | School of Life Science,Beijing Institute of Technology,Beijing 100081,China |
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Abstract: | This study investigated the anti-hypertensive mechanism of rosiglitazone in renovascular hypertensive rats, and examined its relationship to oxidative stress and lipid metabolism. The renovascular hypertension was induced by stenosis of the left renal artery. Four groups of rats were selected: control, induced untreated, rosiglitazone (20.mg/kg) and captopril (10.mg/kg). After 14.d of administration, compared with induced untreated group, rosiglitazone group reduced the renovascular hypertensive rats' systolic blood pressure and diastolic blood pressure, and decreased total cholesterol (TCH), triglyceride (TG), angiotensin II (Ang II) and angiotensin receptor (AT1) levels(P<0.05). Meanwhile, rosiglitazone remarkably decreased the levels of malondialdehyde (MDA) and hydrogen peroxide (H2O2) while improved the levels of supperoxide dismutase (SOD) and reduced glutathione (GSH). These results suggested that rosiglitazone could effectively decreased the blood pressure in renovascular hypertensive rats, and this might be performed by regulating the activity of angiotensin and the lipid metabolism and improving the oxidative stress. |
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Keywords: | rosiglitazone renovascular hypertensive rat lipid metabolism oxidative stress |
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