N,N-二甲基-3-氯丙胺的合成工艺研究

以1-溴-3-氯丙烷和33%二甲胺水溶液为主要原料进行胺的烷基化反应合成N,N-二甲基-3-氯丙胺。通过单因素试验和正交试验的考察,确定了最佳合成工艺条件,即原料摩尔比1∶1.5、反应温度30~35℃、反应时间4.5 h、继续反应时间1.5 h、碱化pH=10~11,总收率70.2%。该实验工艺流程简单、原料易得、成本较低。

Study on the Synthesis of N,N-dimethyl-3-chloropropylamine

1-bromine-3-chlorine propane and 33 % dimethylamine water solution were used as the main raw materials,through the reaction of amine alkylation to conduct the technical research of the synthesis of N,N-dimethyl-3-chloropropylamine.By doing the Single-factor test and the Orthogonal test,the optimal synthesis conditions was determined,the raw materials ratio was 1∶1.5,the reaction temperature was 30~35 ℃,the reaction time was 4.5 h,the continuous reaction time was 1.5 h,the alkalization pH was 10~11,the total yield was 70.2 %.The experimental method was simple and easy for raw materials,lower costs.