ACE-inhibitory activity and gamma-aminobutyric acid content of fermented skim milk by <Emphasis Type="Italic">Lactobacillus helveticus</Emphasis> isolated from Xinjiang koumiss in China |
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Authors: | TianSong Sun ShuPing Zhao HaiKuan Wang CiKe Cai YongFu Chen HePing Zhang |
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Affiliation: | (1) Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, 010018 Huhhot, People’s Republic of China;(2) Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, 300457 Tianjin, People’s Republic of China |
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Abstract: | Eighty-one strains of Lactobacillus were isolated from the koumiss collected in Xinjiang, China. The strains were cultivated in skim milk medium, ACE inhibitory
activity and GABA concentrations in the culture supernatants were measured. Screening results revealed that ACE inhibitory
activity of 16 strains was higher than 50% and two strains produced GABA. The Lactobacillus—ND01 strain produces both the high ACE inhibitory activity and GABA. The sequence of 16S rDNA of the Lactobacillus—ND01 showed 99% homology to L. helveticus. The first identification of the newly isolated Lactobacillus—ND01 strain which produces both high ACE inhibitory activity and GABA revealed differences from reported species in our study.
The L. helveticus ND01 was resistant to acidic condition. The results suggest that L. helveticus ND01 showed good potential for application in the management of hypertension. |
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Keywords: | ACE-inhibitory activity Lactobacillus helveticus γ -Aminobutyric acid Fermented milk Koumiss |
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