| 紫外光照射下富勒醇对细胞的防护作用 |
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| 引用本文： | 李宇国,倪瑾,韩玲,赵群芬,高福,李晴暖,徐晶莹,李文新.紫外光照射下富勒醇对细胞的防护作用[J].辐射研究与辐射工艺学报,2004,22(6):356-360. |
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| 作者姓名： | 李宇国 倪瑾 韩玲 赵群芬 高福 李晴暖 徐晶莹 李文新 |
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| 作者单位： | 中国科学院上海应用物理研究所纳米生物医药研究室,上海,201800;第二军医大学放射医学教研室,上海,200438 |
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| 基金项目： | 国家自然科学基金(30200069和19975066)资助 |
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| 摘 要： | 为了解紫外辐射下富勒烯衍生物富勒醇对细胞的生物效应，利用四唑盐比色实验(MTT)法研究了富勒醇对紫外辐照细胞的存活率影响，紫外辐照细胞时富勒醇对细胞超氧化物岐化酶(SOD)和氧化产物丙二醛(MDA)的影响，同时比较了C60-PVP对紫外辐照细胞的辐射生物效应。结果表明，富勒醇能够有效的防护紫外辐射对细胞造成的损伤，其机理可能是富勒醇能够吸收紫外辐照产生的自由基，使细胞膜不被紫外辐照损伤。
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| 关 键 词： | 富勒烯 紫外辐照 辐射保护 |
| 修稿时间： | 2004年4月30日 |
The effect of fullerols under UV on cell |
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| LIYuguo NI Jin HAN Ling ZHAO Qunfen GAO Fu LI Qingnuan XU Jingying LI Wenxin.The effect of fullerols under UV on cell[J].Journal of Radiation Research and Radiation Processing,2004,22(6):356-360. |
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| Authors: | LIYuguo NI Jin HAN Ling ZHAO Qunfen GAO Fu LI Qingnuan XU Jingying LI Wenxin |
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| Affiliation: | LIYuguo1 NI Jin2 HAN Ling2 ZHAO Qunfen1 GAO Fu2 LI Qingnuan1 XU Jingying1 LI Wenxin1 1 |
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| Abstract: | The UV radioprotcetive effect of fullerols, which was compared with the effect of C60-PVP, was studied using cultured L02 cells. The cell survivals were determined by MTT method, SOD and MDA also were studied with chemistric colorimetry. The results showed that fullerols can effectively protect cells from damage induced by UV irradiation. The mechanism could be assosiated with the ability of fullerols to behave as an antioxidant compound, then fullerols protected cell membrane from damage by UV radiation. |
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| Keywords: | Fullerene Ultraviolet radiation Radioprotective CLC O644 |
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