| 一锅法高产率合成α-羰基苯丁酸 |
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| 引用本文： | 胡惟孝,赵金浩,周卫,杨忠愚. 一锅法高产率合成α-羰基苯丁酸[J]. 精细化工, 2002, 19(5): 289-290,294 |
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| 作者姓名： | 胡惟孝 赵金浩 周卫 杨忠愚 |
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| 作者单位： | 浙江工业大学制药工程研究所,浙江杭州,310014 |
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| 基金项目： | 浙江省自然科学基金资助项目 (2 0 0 0 16) |
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| 摘 要： | 用苯丙酸乙酯与草酸二乙酯合成α 羰基苯丁酸。采用一锅法代替文献中的两步反应 ,用稀硫酸代替文献中盐酸 -醋酸混酸水解 ,并用正交设计法对工艺条件进行优化 ,得出最佳工艺条件为 :n(苯丙酸乙酯 )∶n (草酸二乙酯 ) =1 0∶4 0 ,缩合 1 5h ,用w (H2 SO4) =2 0 %的硫酸水解15h ,产品收率由文献值的 5 7 2 %提高到 89%
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| 关 键 词： | α羰基苯丁酸 苯丙酸乙酯 草酸二乙酯 |
| 文章编号： | 1003-5214(2002)05-0289-03 |
One Pot Synthesis of 2-Oxo-4-phenylbutyric Acid in High Yield |
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| HU Wei xiao,ZHAO Jin hao,ZHOU Wei,YANG Zhong yu. One Pot Synthesis of 2-Oxo-4-phenylbutyric Acid in High Yield[J]. Fine Chemicals, 2002, 19(5): 289-290,294 |
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| Authors: | HU Wei xiao ZHAO Jin hao ZHOU Wei YANG Zhong yu |
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| Abstract: | Synthesis of 2 oxo 4 phenylbutyric acid was conducted in one pot.Ethyl 3 phenylpropionate condensed with diethyl oxalate in the presence of sodium methoxide,then the reaction mixture was hydrolyzed with dilute sulfuric acid directly.The optimum reaction conditions were: m (ethyl 3 phenylpropionate)∶ m (diethyl oxalate)=1∶4,time of condesation 1 5 h and hydrolysis for 15 h with sulfuric acid 〔w(H 2SO 4)=20%〕. The yield reached as high as 89% as compared with 57 2% in the literature. |
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| Keywords: | oxo 4 phenylbutyric acid ethyl 3 phenylpropionate diethyl oxalate |
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