| 2-氨基-6-溴吡啶的合成研究 |
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| 引用本文： | 方永勤,孙德鑫,许亮,吕新宇. 2-氨基-6-溴吡啶的合成研究[J]. 化学世界, 2010, 51(6) |
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| 作者姓名： | 方永勤 孙德鑫 许亮 吕新宇 |
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| 作者单位： | 江苏工业学院精细化工研究所,江苏,常州,213164;江苏工业学院精细化工研究所,江苏,常州,213164;江苏工业学院精细化工研究所,江苏,常州,213164;江苏工业学院精细化工研究所,江苏,常州,213164 |
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| 摘 要： | 2-氨基-6-溴吡啶及其衍生物是重要的药物中间体,以2-氨基-6-甲基吡啶为原料,经重氮化、溴代、氧化、氯化、氨解、霍夫曼降解合成2-氨基-6-溴吡啶。重点考察了氯化、氨解及霍夫曼降解反应条件对收率的影响,总收率34.6%,产品结构经红外、核磁得到确认。
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| 关 键 词： | 2-氨基-6-甲基吡啶 2-氨基-6-溴吡啶 中间体 |
Synthesis of 2-Amino-6-bromopyridine |
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| FANG Yong-qin,SUN De-xin,XU Liang,L Xin-yu. Synthesis of 2-Amino-6-bromopyridine[J]. Chemical World, 2010, 51(6) |
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| Authors: | FANG Yong-qin SUN De-xin XU Liang L Xin-yu |
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| Affiliation: | FANG Yong-qin,SUN De-xin,XU Liang,L(U) Xin-yu |
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| Abstract: | 2-Amino-6-bromopyridine and its derivatives are important pharmaceutical and chemical intermediates.2-Amino-6-bromopyridine was prepared with 2-amino6-methylpyridine as raw material by diazotization,bromation,oxidation,chlorination,amination and Hofmann degradation.The effects of the reaction conditions of chlorination,amination and Hofmann degradation on the yield were investigated.The total yield was 34.6%.The structure of product was identified by IR and ~1H NMR spectroscopy. |
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| Keywords: | 2-amino-6-methylpyridine 2-amino-6-bromopyridine intermediate |
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