Cyclopropyl indolequinones: mechanistic probes for bioreductive anticancer drug action |
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Authors: | CJ Moody CL Norton AM Slawin S Taylor |
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Affiliation: | Department of Chemistry, Loughborough University, Leicestershire, UK. |
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Abstract: | A series of cyclopropyl indolequinones based on structures 5-7 was designed and synthesized to probe the structural features essential for bioreductive cytotoxicity. Ring opening of the cyclopropane ring under radical conditions was demonstrated to be mechanistically feasible, and related to the involvement of such one-electron processes in the cytotoxicity of cyclopropyl indolequinones under hypoxic conditions. |
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