Autoimmune ovarian disease: mechanism of disease induction and prevention |
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Authors: | KS Tung YH Lou KM Garza C Teuscher |
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Affiliation: | Department of Pathology, University of Virginia, Charlottesville 22908, USA. kst7k@Virginia.edu |
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Abstract: | Investigation of the versatile models for autoimmunity of the ovary and other selected organs has contributed to our understanding of the following aspects of autoimmunity: the mechanism of T cell molecular mimicry; T-->B epitope spreading, as a basis for autoantibody diversification, and as a link between organ-specific and systemic autoimmunity; the localization of genetic loci potentially influencing multiple autoimmune diseases; and the elucidation of regulatory T cells as a component of physiological self tolerance. |
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