Porous Se@SiO2 nanospheres inhibit calcium oxalate kidney stone formation by oxidation resistance |
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Affiliation: | Department of Urology, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, 100050, China |
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Abstract: | The prevalence of kidney stones continues to increase worldwide, however, there are still short of effective drugs against urinary stones. In our study, we developed and utilized porous Se@SiO2 nanospheres as the novel antioxidant agent to detect its potential effects on crystallization inhibition. Porous Se@SiO2 nanospheres enable to deliver Se sustainably with lower cytotoxicity and preferred biocompatibility. In vivo, we found that porous Se@SiO2 nanospheres markedly decreased CaOX crystal deposition in renal parenchyma and alleviated kidney oxidative damage. In vitro, we found that the antioxidant effects of porous Se@SiO2 nanospheres were mediated by upregulation of HO-1 and activation of Keap1/Nrf2 pathway. These results suggests that porous Se@SiO2 nanospheres may be a new promising therapeutic option for stone formers. |
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Keywords: | Kidney stones Calcium oxalate Oxidative stress Keap1/Nrf2 pathway |
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