Double-ligand modulation for engineering magnetic nanoclusters |
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| Authors: | Bongjune Kim Jaemoon Yang Eun-Kyung Lim Joseph Park Jin-Suck Suh Hyo Seon Park Yong-Min Huh Seungjoo Haam |
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| Affiliation: | 1.Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University, Seoul, 120-749, Republic of Korea;2.Department of Radiology, College of Medicine, Yonsei University, Seoul, 120-752, Republic of Korea;3.Department of Architectural Engineering, College of Engineering, Yonsei University, Seoul, 120-749, Republic of Korea |
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| Abstract: | Magnetic nanoclusters (MNCs) are agglomerated individual magnetic nanoparticles (MNPs) that show great promise in increasing magnetic resonance imaging (MRI) sensitivity. Here, we report an effective strategy to engineer MNCs based on double-ligand modulation to enhance MRI sensitivity. The oleic acid-coated individual MNPs self-assembled and then were enveloped by polysorbate 80, using a nanoemulsion method to prepare MNCs. By modulating the amounts of the two ligands, and thus the size and magnetic content of the resultant MNCs, we were able to enormously improve MRI sensitivity. |
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| Keywords: | Magnetic nanoparticle Double-ligand modulation Nanoemulsion Magnetic nanocluster Magnetic resonance imaging |
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