MOLECULAR MECHANISMS OF CELL ADHESION: NEW PERSPECTIVES FROM SURFACE FORCE MEASUREMENTS |
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| Authors: | Deborah Leckband |
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| Affiliation: | a Department of Chemical and Biomolecular Engineering and Department of Chemistry, Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA |
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| Abstract: | This review highlights recent surface force measurements of the molecular interactions of protein adhesives. These studies identified novel molecular-binding mechanisms that are intimately linked to the protein structures. Central to these findings is the precise force and distance sensitivity achieved with the surface force apparatus. They illustrate that a mechanistic understanding of the nanomechanical properties of biomolecular adhesives requires measurements of both the strength of adhesion and the range of the protein interactions. |
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| Keywords: | Cell adhesion Surface force apparatus Cadherin NCAM CD2 Polysialic acid |
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