P2O5‐Fe2O3‐CaO‐SiO2 ferromagnetic glass‐ceramics for hyperthermia |
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| Authors: | PengTian Ji YongYa Wang MoRan Zhang Bin Li GuiXiang Zhang |
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| Affiliation: | 1. Department of Radiology, Shanghai General Hospital of Nanjing Medical University, Nanjing, China;2. Department of Interventional Radiology, Huzhou Central Hospital, Huzhou, China;3. Department of Material Chemistry, Huzhou University, Huzhou, China;4. School of Life Science, Huzhou University, Huzhou, China |
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| Abstract: | Ferromagnetic glass‐ceramics are an important kind of thermoseed material for hyperthermia treatments. In order to investigate the applications of glass‐ceramics in magnetic hyperthermia, P2O5‐Fe2O3‐CaO‐SiO2 (PFCS) glass‐ceramics with different compositions were prepared by the sol‐gel method. The crystal phase, magnetic properties, induction heating ability, and cytotoxicity of the as‐prepared glass‐ceramics were investigated. The results show that all the samples exhibit low cytotoxicity and good induction heating ability. Moreover, it was found that the phosphorus content affected the crystal phase component of the sample, and thus influenced the induction heating ability. Results of the magnetic hyperthermia experiments showed that the PFCS glass‐ceramic samples induced significant cell death of the LoVo cancer cells. The highest cell death rate for sample B2P7 was more than 95%, which suggests good application prospects in the field of hyperthermia therapy. |
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| Keywords: | cytotoxicity glass‐ceramics induction heating ability magnetic hyperthermia |
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