A concise synthesis and in vitro cytotoxicity of new labdane diterpenes |
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| Authors: | M Jung I Ko S Lee SJ Choi BH Youn SK Kim |
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| Affiliation: | Department of Chemistry, Yonsei University, Seoul, Korea. |
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| Abstract: | A new series of labdane-related diterpenes have been synthesized from (-)-sclareol and assayed in vitro cytotoxicity against mouse and human cancer cells. A key intermediate, homodrimane and furanolabdane derivatives show good in vitro cytotoxicity comparable to those of mitomycin C and adriamycin. |
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