| 氟噻草胺的合成 |
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| 引用本文： | 姜育田,陈同明,李茂青. 氟噻草胺的合成[J]. 农药, 2007, 46(11): 734-736 |
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| 作者姓名： | 姜育田 陈同明 李茂青 |
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| 作者单位： | 江苏安邦电化有限公司,江苏,淮安,223002;江苏安邦电化有限公司,江苏,淮安,223002;江苏安邦电化有限公司,江苏,淮安,223002 |
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| 摘 要： | 改进了除草剂氟噻草胺的合成方法。以肼基二硫代甲酸甲酯、三氟乙酸为原料合成2-甲砜基-5-三氟甲基-1,3,4-噻二唑(4),反应收率81.5%;以对氟硝基苯、丙酮经过催化加氢、酰化、醇解合成N-(4-氟苯基)-N-异丙基-2-羟甲基乙酰胺(8)。化合物(4)与(8)反应合成氟噻草胺,得率94.2%。改进后的工艺反应条件温和,三废少,产品纯度和收率高。
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| 关 键 词： | 氟噻草胺 合成 除草剂 |
| 文章编号： | 1006-0413（2007）11-0734-03 |
| 修稿时间： | 2007-06-04 |
Synthesis of Flufenacet |
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| JIANG Yu-tian,CHEN Tong-ming,LI Mao-qing. Synthesis of Flufenacet[J]. Pesticides, 2007, 46(11): 734-736 |
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| Authors: | JIANG Yu-tian CHEN Tong-ming LI Mao-qing |
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| Affiliation: | Jiangsu Anpon Electrochemical Co., Ltd., Huaian 223002, Jiangsu, China |
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| Abstract: | Herbicide flufenacet was synthesized by reaction of 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole with N-(4-fluorophenyl)-2-hydroxy-N-isopropylacetamide with the yield of 94.2%. 2-(Methylsulfonyl)-5- (trifluoromethyl)-1,3,4-thiadiazole was prepared by reaction of methyl hydrazinecarbodithioate with trifluoroacetic acid with the yield of 81.5%. N-(4-Fluorophenyl)-2-hydroxy-N-isopropylacetamide was synthesized by using 1-fluoro-4-nitrobenzene as a starting material in four-step procedure. |
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| Keywords: | flufenacet synthesis herbicide |
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