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| 80MeV/u 12C6+离子辐照小鼠头部对骨髓细胞周期分布的影响 | |
| 引用本文： | 邴涛,党秉荣,谢漪,邱嵘,李文建,荆西刚,李强,胡清荣,高波,张永东,梁涛,李德杏.80MeV/u 12C6+离子辐照小鼠头部对骨髓细胞周期分布的影响[J].核技术,2006,29(11):842-844. |
| 作者姓名： | 邴涛 党秉荣 谢漪 邱嵘 李文建 荆西刚 李强 胡清荣 高波 张永东 梁涛 李德杏 |
| 作者单位： | 1. 中国科学院近代物理研究所,兰州,730000;中国科学院研究生院,北京,100049 2. 中国科学院近代物理研究所,兰州,730000 3. 甘肃省医学科学院,兰州,730050 |
| 基金项目： | 中国科学院基金 , 国家自然科学基金 , 中国科学院兰州近代物理研究所资助项目 , 甘肃省青年科技基金 |
| 摘 要： | 研究重离子辐照小鼠头部对骨髓细胞周期分布的影响,为重离子放射治疗癌症和太空防护提供基础数据.80MeV/u能量的12C6 离子对BALB/c小鼠头部给以0、0.5、1、2、4、10Gy的照射,用流式细胞仪测骨髓细胞周期分布.随着重离子辐照剂量的增加,G1/G0期细胞出现明显阻滞(P＜0.05),而G2/M期细胞出现显著减少(P＜0.05).说明重离子辐照小鼠头部对小鼠骨髓细胞周期分布有明显影响,也同时表明电离辐射对骨髓细胞周期分布的影响也有一种间接作用. |
| 关 键 词： | 重离子辐照 骨髓细胞 细胞周期分布 |
| 收稿时间： | 2006-03-15 |
| 修稿时间： | 2006-03-152006-06-20 |
Effects of 80MeV12C+6/u ion irradiation on bone marrow cell cycle distribution of mice |
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| BING Tao,DANG Bingrong,XIE Yi,QIU Rong,LI Wenjian,JING Xigang,LI Qiang,HU Qingrong,GAO Bo,ZHANG Yongdong,LIAN Tao,LI Dexing.Effects of 80MeV12C+6/u ion irradiation on bone marrow cell cycle distribution of mice[J].Nuclear Techniques,2006,29(11):842-844. | |
| Authors: | BING Tao DANG Bingrong XIE Yi QIU Rong LI Wenjian JING Xigang LI Qiang HU Qingrong GAO Bo ZHANG Yongdong LIAN Tao LI Dexing |
| Affiliation: | 1. Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000, China; 2. Graduate School of Chinese Academy of Sciences, Beijing 100049, China ; 3. Gansu Academy of Medical Sciences, Lanzhou 730050, China |
| Abstract: | The heads of the BALB/c mice were irradiated with 0, 0.5, 1, 2, 4 or 10 Gy of 12 C 6+ ions (80MeV/ u) and then the cell cycle distribution was analyzed by flow cytometry. At 36 h after irradiation, the G1/G0 phase cells were arrested significantly (P<0.05) with the increase of irradiated dose, while the G2/M phase cells were reduced markedly (P<0.05). After whole head irradiation (WHI) with heavy ions, the bone marrow cell cycle distribution of mice had significant changes, which indicates that ionization radiation may have an indirect effect on the bone marrow cell cycle distribution. |
| Keywords: | Heavy ion irradiation Bone marrow Cell cycle distribution |
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