Isolated limb perfusion of an irradiated foot with tumor necrosis factor, interferon, and melphalan |
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Authors: | RJ van Ginkel HJ Hoekstra AM Eggermont E Pras HS Koops |
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Affiliation: | Department of Surgical Oncology, Groningen University Hospital, The Netherlands. |
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Abstract: | A 57-year-old woman presented with the second recurrence of a high-grade malignant fibrous histiocytoma of the right foot, following previous local resection plus curative adjuvant radiotherapy. The first recurrence of the lesion was treated by isolated limb perfusion with cisplatin; the second recurrence was treated by isolated limb perfusion with tumor necrosis factor, interferon, and melphalan. The tumor and the area that had been irradiated showed a bluish color a few hours after tumor necrosis factor perfusion. Amputation of the right foot and leg below the knee had to be performed because of severe necrosis. |
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