Detection of selected stimulants as contaminants in solid nutritional supplements by liquid chromatography–mass spectrometry |
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| Authors: | K. Deventer,W. Van Thuyne,P. Mikulčí ková ,P. Van Eenoo,F.T. Delbeke |
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| Affiliation: | 1. Department of Clinical Chemistry, Microbiology and Immunology, Doping Control Laboratory (DoCoLab), Ghent University – UGent, Technologiepark 30, B-9052 Zwijnaarde, Belgium;2. Department of Analytical Chemistry, University of Pardubice, nám. ?s. legií 565, 532 10 Pardubice, Czech Republic |
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| Abstract: | Nutritional supplements are frequently used by athletes and can contain substances banned by the World Anti Doping Agency (WADA). The aim of this study was to develop a screening method for the detection of selected stimulants in solid nutritional supplements. Analysis of the samples was performed on an LCQ-Deca® instrument after an acidic wash with n-pentane and an alkaline liquid/liquid extraction with diethylether. The mass spectrometer was operated in full scan MS2 using positive ionisation. Detection limits (LODs) were equal or below 50 ng/g for all compounds except strychnine (100 ng/g). The suitability of the method for routine application was illustrated by the analysis of two suspicious samples. |
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| Keywords: | Doping Stimulants LC&ndash MS APCI Nutritional supplements |
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