Antioxidant abietane diterpenoids from Salvia barrelieri |
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Authors: | Ahmed Kabouche Zahia Kabouche Mehmet Öztürk Ufuk Kolak Gülaçtı Topçu |
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Affiliation: | 1. Faculté des Sciences, Laboratoire d’Obtention de Substances Thérapeutiques (LOST), Université Mentouri-Constantine, Constantine 25000, Algeria;2. Department of General Chemistry and Analytical Chemistry, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey;3. Department of Chemistry, Faculty of Science and Arts, Mugla University, Mugla 48000, Turkey;4. Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey |
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Abstract: | The root extract of endemic Algerian Salvia species Salvia barrelieri Ettling and its diterpenoids were investigated for potential antioxidant activity. From its acetone extract, a new natural abietane diterpenoid 7-oxoroyleanone-12-methyl ether (1) and six known diterpenoids 7α-acetoxyroyleanone-12-methyl ether (2), royleanone (3), horminone (4), 7-acetylhorminone (5), cryptojaponol (6) and inuroyleanol (7) were isolated, and their structures were elucidated by spectroscopic means. Among the diterpenoids, the new diterpenoid 7-oxoroyleanone-12-methyl ether (1) showed highest superoxide anion scavenging activity while inuroyleanol (7) showed both the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and inhibition of lipid peroxidation in β-carotene–linoleic acid system. These findings indicate that S. barrelieri extract as well as isolated abietane diterpenes, particularly inuroyleanol are promising antioxidants which can be used as food additives. |
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Keywords: | Antioxidant activity S barrelieri Lamiaceae Abietane diterpenoids 7-Oxoroyleanone-12-methyl ether |
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