| 全反式替普瑞酮的化学全合成研究 |
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| 引用本文： | 黄栋,陈志荣,尹红. 全反式替普瑞酮的化学全合成研究[J]. 化学试剂, 2005, 27(11): 641-642,661 |
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| 作者姓名： | 黄栋 陈志荣 尹红 |
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| 作者单位： | 浙江大学,材料与化工学院,浙江,杭州,310027;浙江大学,材料与化工学院,浙江,杭州,310027;浙江大学,材料与化工学院,浙江,杭州,310027 |
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| 摘 要： | 以香叶醇和乙酸香叶酯为原料，香叶醇经溴化和亚磺酰化两步反应合成香叶基砜（3），乙酸香叶酯经氧化、还原和溴化3步反应合成中间体6，化合物3和6偶联的产物在锂胺溶液中脱除砜基得到香叶基香叶醇（8），化合物8经溴化、烷基化和脱羧3步反应合成全反式替普瑞酮（10）。
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| 关 键 词： | 香叶醇 乙酸香叶酯 偶联 脱砜 香叶基香叶醇 全反式替普瑞酮 |
| 文章编号： | 0258-3283（2005）11-0641-02 |
| 收稿时间： | 2005-04-02 |
| 修稿时间： | 2005-04-02 |
Study on chemical synthesis of all trans-teprenone |
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| HUANG Dong,CHEN Zhi-rong,YIN Hong. Study on chemical synthesis of all trans-teprenone[J]. Chemical Reagents, 2005, 27(11): 641-642,661 |
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| Authors: | HUANG Dong CHEN Zhi-rong YIN Hong |
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| Affiliation: | College of Material and Chemical Engineering, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | All trans-teprenone was obtained through desulfonylation, bromination, alkylation and decarboxylation of coupling product of 3 and 6. Through the reaction with sodium sulfinate, the bromination product of trans-geraniol was turned to 3. 6 was obtained by reduction and bromination of the oxidation product of geranyl acetate. |
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| Keywords: | geraniol geranyl acetate coupling desulfonylation geranylgeraniol all trans-teprenone |
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