Differential Scanning Calorimetry of Cephalexin-Dextrose and Cephalexin-Aspartame Mixtures |
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| Authors: | Hamed H. El-Shattawy Dane O. Kildsig Garnet E. Peck |
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| Affiliation: | a Department of Pharmaceutics, Division of Pharmacy, Faculty of Medicine, Al-Azhar University, Nasr-City, Cairo, Egyptb Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, USA |
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| Abstract: | The possible interaction of cephalexin with anhydrous dextrose and with aspartame, in the solid state, was investigaged by comparing the thermal behavior of physical mixtures of the respective original components in different molar ratios, using differential scanning calorimetry. Both anhydrous dextrose and aspartame were found to form complexes with cephalexin. The stoichiometries of these complexes were found to be 1:1 molar complexes between cephalexin and anhydrous dextrose and 4:1 and 1:1 molar complexes between cephalexin and aspartame. Complexed cephalexin was found to decompose at markedly lower temperatures than uncomplexed cephalexin. |
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