Liver proteins as sensor of human malignancies and inflammation |
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Authors: | Peracaula Rosa Sarrats Ariadna Rudd Pauline M |
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Affiliation: | Unitat de Bioquímica i Biologia Molecular, Departament de Biologia, Universitat de Girona, Campus de Montilivi, Girona, Spain. |
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Abstract: | In this review we would like to highlight the importance of acute-phase proteins as sensor of diseases. Both acute-phase protein levels and glycosylation have been reported to be altered in inflammation and other diseases including cancer. Factors that promote acute-phase protein synthesis and enhance the expression of specific glycosyltransferases, such as sialyltransferases and fucosyltransferases, may be up-regulated in some tumours and would explain the changes in acute-phase protein levels and the specific N-glycosylation modifications of some acute-phase proteins in cancer. However, further studies are required to define the potential clinical application of these acute-phase protein cancer-specific modifications as possible cancer diagnostic or monitoring tools. |
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