Issues in the Reconstruction of Gene Order Evolution |
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Authors: | David Sankoff Chunfang Zheng Adriana Muñoz Zhenyu Yang Zaky Adam Robert Warren Vicky Choi Qian Zhu |
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Affiliation: | David Sankoff,Chunfang Zheng,Adriana Mu(n)oz,Zhenyu Yang,Zaky Adam,Robert Warren,Vicky Choi,Qian Zhu |
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Abstract: | As genomes evolve over hundreds of millions years, the chromosomes become rearranged, with segments of some chromosomes inverted, while other chromosomes reciprocally exchange chunks from their ends. These rearrangements lead to the scrambling of the elements of one genome with respect to another descended from a common ancestor. Multidisciplinary work undertakes to mathematically model these processes and to develop statistical analyses and mathematical algorithms to understand the scrambling in the chromo... |
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Keywords: | chromosome rearrangement comparative genomics gene clusters phylogenomics |
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