Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: Hydrolytically degradable materials |
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Authors: | Martin P?ádný Ji?í Michálek Petr Lesný Ale? Hej?l Ji?í Vacík Miroslav ?louf Eva Syková |
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Affiliation: | (1) Academy of Sciences of the Czech Republic, Institute of Macromolecular Chemistry, 162 06 Prague 6, Czech Republic;(2) Center for Cell Therapy and Tissue Repair, Charles University, 150 06 Prague 5, Czech Republic;(3) Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague 4, Czech Republic |
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Abstract: | Macroporous hydrogels based on 2-hydroxyethyl methacrylate, 2-ethoxyethyl methacrylate and N-(2-hydroxypropyl)methacrylamide, methacrylic acid and 2-(methacryloyloxy)ethyl]trimethylammonium chloride crosslinked with
N,O-dimethacryloylhydroxylamine were prepared. Hydrogels were degraded in a buffer of pH 7.4. Completely water-soluble polymers
were obtained over time periods ranging from 2 to 40 days. The process of degradation was followed gravimetrically and by
optical and electron microscopy. In vivo biological tests with hydrogels based on copolymers of 2-ethoxyethyl methacrylate/N-(2-hydroxypropyl)methacrylamide were performed. |
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