Biomaterials control of pluripotent stem cell fate for regenerative therapy |
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Affiliation: | 1. Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Republic of Korea;2. Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Republic of Korea;3. Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 330-714, Republic of Korea;4. Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA;5. Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA;1. School of Physics & Material Science, Anhui University, Hefei 230601, PR China;2. School of Electronic & Information Engineering, Hefei Normal University, Hefei 230601, PR China;3. National Laboratory for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, PR China;4. School of Mechanical & Electronic Engineering, Chuzhou University, Chuzhou 239000, PR China;1. Group of Epigenetic Reprogramming, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;1. Laboratoire d׳énergétique et d׳électrochimie du solide, Département de génie des procédés, Faculté de Technologie, U. F. A. Sétif 1, Sétif 19000, Algérie;2. Institut d׳Optique et mécanique, Université Ferhat Abbas Sétif 1, Sétif 19000, Algérie;1. R & D Division, Tata Steel, Jamshedpur, Jharkhand 831001, India;2. Department of Materials Engineering, McGill University, H3A 2B2 Montreal, Canada;1. Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, China;2. College of Life Science and Biotechnology, MianYang Teachers’ College, Mianyang 621006, Sichuan, China;3. Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, School of Mechanical Engineering, Tianjin University, Tianjin 300072, China;4. National Engineering Research Center for Biomaterials, Sichuan University, 610065 Chengdu, Sichuan, China;5. Department of Polymer Science and Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China;1. School of Bioscience and Engineering, Jadavpur University, Kolkata, India;2. Bioceramics and Coating Division, CSIR-Central Glass and Ceramic Research Institute, Kolkata, India;3. Department of Mechanical Engineering, Jadavpur University, Kolkata, India;4. Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Science, Kolkata, India |
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Abstract: | Pluripotent stem cells (PSCs) derived from either the embryo or reprogramming processes have the capacity to self-renew and differentiate into various cells in the body, thereby offering a valuable cell source for regenerative therapy of intractable disease and serious tissue damage. Traditionally, methods to expand and differentiate PSCs have been confined to 2D culture through the use of biochemical signals; the use of biomaterials beyond the commercially available culture dish has not been widespread. Nevertheless, biomaterials with tailored physical, chemical, and geometrical cues can mimic the native stem cell niche to tune the microenvironmental conditions for PSCs to preserve their self-renewal capacity or to switch their phenotype, a status ultimately needed to gain regenerative functions ex vivo and in vivo. Recently efforts to explore biomaterials to regulate PSC behavior have accelerated. The biomaterials properties investigated include surface chemistry, immobilized ligand, nano-/micro-topography, matrix stiffness, geometrical complexity, 3D configuration, and combinations thereof. This review aims to cover the current advances of biomaterials-based control over PSCs, particularly for the preservation of self-renewal capacity as well as for their differentiation into target cells. Furthermore, it aims to suggest future research directions that would facilitate the eventual translation of these advances. |
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Keywords: | Pluripotent stem cells Self-renewal Lineage differentiation Biomaterials Microenvironment |
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