Prediction of protein structural classes by support vector machines |
| |
Authors: | Cai Yu-Dong Liu Xiao-Jun Xu Xue-biao Chou Kuo-Chen |
| |
Affiliation: | Shanghai Research Centre of Biotechnology, Chinese Academy of Sciences. y.cai@umist.ac.uk |
| |
Abstract: | In this paper, we apply a new machine learning method which is called support vector machine to approach the prediction of protein structural class. The support vector machine method is performed based on the database derived from SCOP which is based upon domains of known structure and the evolutionary relationships and the principles that govern their 3D structure. As a result, high rates of both self-consistency and jackknife test are obtained. This indicates that the structural class of a protein inconsiderably correlated with its amino and composition, and the support vector machine can be referred as a powerful computational tool for predicting the structural classes of proteins. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |