Optimization of cardiac cine in the rat on a clinical 1.5-T MR system |
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Authors: | K. Montet-Abou J. L. Daire M. K. Ivancevic J. N. Hyacinthe D. Nguyen M. Jorge-Costa D. R. Morel J. P. Vallée |
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Affiliation: | (1) Radiology and Medical Informatics Department, Digital Imaging Unit (UIN), Geneva University Hospital, 1211 Geneva 14, Switzerland;(2) Anesthesiology, Pharmacology and Intensive Care in Surgery Department, Anesthesiological Investigations Unit, Geneva University Hospital, 1211 Geneva 14, Switzerland |
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Abstract: | Object: the overall goal was to study cardiovascular function in small animals using a clinical 1.5-T MR scanner optimizing a fast gradient-echo cine sequence to obtain high spatial and temporal resolution. Materials and methods: normal rat hearts (n = 9) were imaged using a 1.5-T MR scanner with a spiral fast gradient-echo (fast field echo for Philips scanners) sequence, three Cartesian fast gradient-echo (turbo field echo for Philips scanners) sequences with different in-plane resolution, and with and without flow compensation and half-Fourier acquisition. The hearts of four rats were then excised and left-ventricle mass was weighed. Inter- and intra-observer variability analysis was performed for magnetic resonance imaging (MRI) measurements. Results: half-Fourier acquisition with flow compensation gave the best sequence in terms of image quality, spatial as well as temporal resolution, and suppression of flow artifact. Ejection fraction was 71 ± 4% with less than 5% inter- and intra-observer variability. A good correlation was found between MRI-calculated left-ventricular mass and wet weight. Conclusions: using optimized sequences on a clinical 1.5-T MR scanner can provide accurate quantification of cardiac function in small animals and can promote cardiovascular research on small animals at 1.5-T |
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Keywords: | MRI Cardiac imaging Small animal |
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