| Synthesis, Characterization of α-Oxopentanedioic Acid-Isonicotinoyl Hydrazone Rare Earth-Complexes and Relaxivity of Gd-complex |
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| 引用本文： | 杨正银,杨汝栋.Synthesis, Characterization of α-Oxopentanedioic Acid-Isonicotinoyl Hydrazone Rare Earth-Complexes and Relaxivity of Gd-complex[J].中国稀土学报(英文版),2004,22(3):327-330. |
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| 作者姓名： | 杨正银 杨汝栋 |
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| 作者单位： | State Key Laboratory of Applied Organic Chemistry，Lanzhou University，Lanzhou 730000，China，State Key Laboratory of Applied Organic Chemistry，Lanzhou University，Lanzhou 730000，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina ( 2 9975 0 12 ) |
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| 摘 要： | Themagneticresonanceimaging (MRI)tech niqueforthemedicineisveryusefultodiagnosepre tumorandbloodvesseldiseaseinheartandbrainandothermalignantpre diseases .Therefore ,specialatten tionhasbeenalsopaidtoMRIcontrastagents ,whichareindispensablediagnosingdrugsforthemagneticresonanceimagingtechnique1,2 ] .Gadolinium (Ⅲ)complexwithsomepolycarboxylicandpolyaminelig ands ,suchasGd(DTPA)·nH2 O ,waswidelyusedincliniclongago .OurpreviousworkshowsthatsomepolycarboxylicSchiffbasecomplexeswithrareea…
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| 关 键 词： | 无机化学 造影剂 稀土复合物 核磁共振 钆 合成 |
Synthesis, Characterization of α-Oxopentanedioic Acid-Isonicotinoyl Hydrazone Rare Earth-Complexes and Relaxivity of Gd-complex |
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| Abstract: | α-Oxopentanedioic acid isonicotinoyl hydrazone (H2L) and its five rare earth complexes were synthesized with a view to further investigating MRI activities of the polycarboxylic Schiff base complexes. The complexes were characterized on the basis of elemental analyses, IR, UV, 1H NMR spectra and thermal analyses. The general formula of the complexes is Ln(HL)(H2O)2]Cl2·H2O (where Ln(Ⅲ)=La, Pr, Nd, Eu and Gd). In addition, the relaxivity (R1) of the Gd-complex was determined by INVREC Au program. |
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| Keywords: | inorgonic chemistry MRI contrast agent Relaxivity rare earth complexes |
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