| Abstract: | Recent Results of Clinical Research on Lipid Metabolism Physiology and pathophysiology of serum lipids are primarily related to lipoprotein metabolism. Physico-chemically, lipoproteins can be separated into four classes which interconvert in plasma: chylomicrons, very low density lipoproteins (VLDL), low density lipoproteins (LDL), and high density lipoproteins (HDL). VLDL originate from liver and are – as LDL – catabolized in liver. LDL are responsible for the development of severe atherosclerosis. Clinically, we distinguish primary hyperlipoproteinemias, which are genetically determined, and secondary forms of hyperlipoproteinemia. Most of these metabolic disorders are risk factors for atherosclerosis and especially for myocardial infarction. This is demonstrated by pathophysiological and clinical data. In addition, possibilities to influence hyperlipoproteinemia are discussed. There exist a great number of studies of primary and secondary prevention which are discussed with regard to their clinical and epidemiological relevance. In this connexion, the effects of dietary and drug treatment are discussed, and the role of polyunsaturated fatty acids is critically evaluated. |
