Mutational specificity of the syn 1,2-dihydrodiol 3,4-epoxide of 5-methylchrysene |
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Authors: | JE Page J Pataki RG Harvey A Dipple |
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Affiliation: | Chemistry of Carcinogenesis Laboratory, NCI Frederick Cancer Research and Development Center, MD 21702-1201, USA. |
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Abstract: | The mutational specificity of the syn dihydrodiol epoxide of 5-methylchrysene in the supF gene of the pSP189 vector was examined. Transversion mutations at GC pairs predominated with G --> T and G --> C changes accounting for 42 and 21% of total base change mutations. The types of mutations found reflect the previously determined chemical preference of this reactive species for reaction with deoxyguanosine residues in DNA. |
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