Enantioseparation of 3-chlorophenylglycine enantiomers using Mandyphos-Pd as chiral extractant |
| |
Authors: | Xiong Liu Shuhuan Chen Yu Ma Wenjie Xiao |
| |
Affiliation: | 1.School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China;2.Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Xiangtan 411201, China |
| |
Abstract: | Chiral extractant plays a key role in chiral extraction, and considerable efforts have been undertaken for the development of new and efficient chiral extractants in recent years. This work demonstrated for the first time that chiral ferrocenyl diphosphine ligand (Mandyphos-Pd) had considerable ability to enantioseparate 3-Chlorophenylglycine enantiomers with separation factor (α) of 2.64. Mandyphos-Pd concentration and pH had significant influences on enantioselectivity, while operating temperature showed less influence. The extraction experiments can be performed at room temperature (20 ℃) which had the advantage of energy saving. After optimization, the highest performance factor (pf, 0.08376) was obtained at the condition of pH 7.8 and Mandyphos-Pd concentration 1.2 mmol·L-1. According to the experimental results, the possible recognition mechanism was discussed. |
| |
Keywords: | Enantioseparation Mandyphos 3-Chlorophenylglycine Response surface method Recognition mechanism |
本文献已被 CNKI 万方数据 等数据库收录! |
| 点击此处可从《中国化学工程学报》浏览原始摘要信息 |
|
点击此处可从《中国化学工程学报》下载全文 |
|