| 低聚壳聚糖的辐射防护作用小鼠试验研究 |
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| 引用本文： | 郭剑平,杨仲田,张华屏. 低聚壳聚糖的辐射防护作用小鼠试验研究[J]. 辐射防护通讯, 2010, 30(2): 23-25 |
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| 作者姓名： | 郭剑平 杨仲田 张华屏 |
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| 作者单位： | 中国辐射防护研究院,太原,030006;山西医科大学,太原,030001 |
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| 基金项目： | "十一五"国防基础科研 |
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| 摘 要： | 采用^60Coγ射线全身照射清洁级SX1近交系小鼠,观察口服给予低聚壳聚糖对小鼠的辐射防护作用。结果表明：与单纯照射组相比,给药组的30 d存活率提高了10%-30%,平均存活天数提高5.2-9.2 d,保护指数提高了1.5-1.8倍;给药组骨髓有丝分裂指数较单纯照射组高,其中,照射剂量为3.15、3.94 Gy组的差异显著;低聚壳聚糖对SX1小鼠的剂量减低系数为1.51。
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| 关 键 词： | 低聚壳聚糖 辐射防护 剂量减低系数 |
Study on Radiation Protection Effect of Oligo-chitosan for Mice |
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| Guo Jianping,Yang Zhongtian,Zhang Huaping. Study on Radiation Protection Effect of Oligo-chitosan for Mice[J]. Radiation Protection Bulletin, 2010, 30(2): 23-25 |
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| Authors: | Guo Jianping Yang Zhongtian Zhang Huaping |
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| Affiliation: | Guo Jianping Yang Zhongtian(China Institute for Radiation Protection,Taiyuan,030006)Zhang Huaping(Shanxi Medical University,030001) |
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| Abstract: | Radiation protection effect was studied of Oligo-chitosan on SX1 mice irradiated by ^60Co γ ray.The results show that Oligo-chitosan could increase 30 d survival rate,averaged on 5.29.2 days.Protection indexes were 1.5-1.8,DRF is 1.51.Oligo-chitosan has obvious radiation protection effect on mice. |
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| Keywords: | Oligo-chitosan Radiation protection DRF |
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