Effect of electrolyte pH on the structure andin vitro osteoblasts response to anodic titanium oxide |
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Authors: | Madhav Prasad Neupane Yu Kyoung Kim Il Song Park Sook Jeong Lee Min Ho Lee Tae Sung Bae |
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Affiliation: | (1) Department of Bionanosystem Engineering, Chonbuk National University, 664-14, Deokjin-dong-1-ga, Deokjin-gu, Jeonju-si, 561-756 Jeonbuk, Korea;(2) Department of Dental Biomaterials and Institute of Oral Bioscience, School of Dentistry, Chonbuk National University, 561-756 Jeonbuk, Korea;(3) Department of Neurology, Asan Life Science Institute, College of Medicine, University of Ulsan, San 29, Mugeo-dong, Nam-gu, 680-749 Ulsan, Korea |
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Abstract: | This study examines the surface morphology, microstructure, and chemical composition of titanium surfaces treated by anodic
spark oxidation in phosphate buffer solution at pH 2, 7 and 12. The pH of the electrolyte was found to play a substantial
role in the formation of different morphologies, chemical compositions, and pore dimensions with microporous structures. SEM
revealed variation in the topologies of the anodized surface with electrolyte pH. Porous structures with uniform pores and
high roughness were obtained in pH 12 solutions. However, intense anatase crystal was obtained at pH 7. The relationship between
surface characteristics of titanium and initial interactions of titanium-osteoblasts was also in vestigated. Our findings
demonstrated the cell viability and proliferation on the anodic oxides produced at pH 12 to be superior to those produced
at pH 2 and 7 as well as on the control titanium surface. This study also provides evidence of enhanced osteoblast adhesion
on anodized metal substrates under in vitro conditions. |
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Keywords: | anodization cell viability microstructure bioactivity osteoblast |
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