The State of the Art of Piezo1 Channels in Skeletal Muscle Regeneration |
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| Authors: | Annalisa Bernareggi Alessandra Bosutti Gabriele Massaria Rashid Giniatullin Tarja Malm Marina Sciancalepore Paola Lorenzon |
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| Affiliation: | 1.Department of Life Sciences, University of Trieste, 34127 Trieste, Italy; (A.B.); (G.M.); (M.S.); (P.L.);2.A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland; (R.G.); (T.M.) |
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| Abstract: | Piezo1 channels are highly mechanically-activated cation channels that can sense and transduce the mechanical stimuli into physiological signals in different tissues including skeletal muscle. In this focused review, we summarize the emerging evidence of Piezo1 channel-mediated effects in the physiology of skeletal muscle, with a particular focus on the role of Piezo1 in controlling myogenic precursor activity and skeletal muscle regeneration and vascularization. The disclosed effects reported by pharmacological activation of Piezo1 channels with the selective agonist Yoda1 indicate a potential impact of Piezo1 channel activity in skeletal muscle regeneration, which is disrupted in various muscular pathological states. All findings reported so far agree with the idea that Piezo1 channels represent a novel, powerful molecular target to develop new therapeutic strategies for preventing or ameliorating skeletal muscle disorders characterized by an impairment of tissue regenerative potential. |
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| Keywords: | Piezo1 myogenesis Yoda1 myoblasts satellite cells myotubes sarcopenia muscle atrophy |
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